ABSTRACT
Objective To evaluate the influence of different types of needleless connector on central venous catheter-related thrombotic occlusions. Methods A detailed search was performed to identify literature about the impact of needleless connector on central venous catheter-related thrombotic occlusions , using the Cochrane Library and the databases of Pubmed,EMbase,CINAHL,CBM,CNKI and WanFang. The meta-analysis or descriptive review were performed after two authors independently searching databases,extracting data and assessing quality of included studies. Results Nine published studies were included for systematic review,which contained three randomized controlled trials,three non-randomized experimental studies and three retrospective observational studies. The results of meta-analysis for five studies showed that the split septum connector was associated with a significantly higher incidence of catheter-related thrombotic occlusions(complete occlusions and partial occlusions) than positive-displacement mechanical valve(RR=0.59,95％CI0.39-0.91,P=0.02). Standard connector and negative- displacement mechanical valve had a higher occlusions rates than positive- displacement mechanical valve ,but the difference did not reach statistical significance after merging the studies( P>0.05). Conclusion It is difficult to decide which needleless connector has the lowest rate of central venous catheter-related thrombotic occlusions because of the insufficient evidence. More large-scale and high-quality randomized controlled trials are required for further confirmation.
ABSTRACT
OBJECTIVE:To study the characteristics and regular pattern of adverse drug reactions(ADR) occurred in our hospital so as to promote rational clinical drug use.METHODS:141 ADR reports collected in our hospital from Sep.2004 to Dec.2007 were analyzed retrospectively.RESULTS:Of the total 141 ADR cases,female comprising 65.25%(92 cases),and 86 cases(60.99%) aged 19～60 years,87 cases(61.70%) were induced by intravenous drip,74 cases(52.11%) were induced by anti infectives,and 34 cases(23.94%) manifested as lesion of skin and its appendants.CONCLUSION:ADR monitor work should be strengthened so as to ensure safe and effective medication.